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Acute mastoiditis caused by Klebsiella pneumoniae carbapenemase (KPC) producing bacteria – an atypical cause

Year: 2026

Type: article

Abstract: Aim: carbapenemase (KPC) producing bacteria. Methods: The following report describes a 78-year-old immunosuppressed female who was hospitalized due to left-sided acute otitis media complicated by tympanic membrane rupture and acute mastoiditis. Fluid-discharge culture revealed KPC. The patient successfully received four weeks of conservative treatment with intravenous colistin (based on antibiotic susceptibilities). Discussion: . Acute mastoiditis caused by KPC-producing bacteria has rarely been reported in medical literature, with most such infections observed following neurosurgical surgeries and/or post-trauma. Conclusion: The incidence of infection by KPC is rising, especially in immunosuppressed patients and those with recent and/or prolonged hospitalizations. There are very few reports in the literature describing acute mastoiditis caused by KPC. Infection with KPC not only has a high 30-day mortality rate (up to 40%) but also poses a significant financial burden on the healthcare system.

Source: PubMed

DOI: 10.3205/dgkh000619

Authors: Aristodimou, Aristos, Raptopoulos, Zacharias, Georgiou, Georgios, Xenofontos, Elena, Dramiotou, Loukia

Institution: Limassol General Hospital

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7127979313

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