Work

Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies

Year: 2026

Type: article

Abstract: Postoperative delirium (POD) is a common acute neuropsychiatric syndrome occurring during the perioperative period, characterized by disturbances in consciousness, attention, and cognition. It frequently develops in elderly patients as a consequence of surgery-induced neurofunctional impairment and physiological stress. Clinically, POD manifests with an abrupt onset, fluctuating course, and symptoms such as confusion and disorganized thinking. Multiple predisposing and precipitating factors contribute to its occurrence, including preoperative mental status, general physical condition, diabetes mellitus, electrolyte imbalances, type and duration of surgery, intraoperative blood loss, anesthesia management, and medication use. Understanding the underlying mechanisms of POD in older adults and implementing targeted preventive and therapeutic interventions are crucial for reducing its incidence, enhancing perioperative recovery, and improving the overall safety of surgical care in the elderly population.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2026.1759910

Authors: Xuan-yin Ding, Ming-hui Zhang, Jun Liu, Dan Wu

Institution: Affiliated Hospital of Southwest Medical University

Language: English

Topic: Intensive Care Unit Cognitive Disorders

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801