Multicenter initiative to standardize management of pediatric immune thrombocytopenia improves adherence to guidelines
Year: 2026
Type: article
Abstract: ABSTRACT: Practice variation exists in the management of newly diagnosed pediatric immune thrombocytopenia (ITP) despite the availability of evidence-based treatment guidelines. The American Society of Hematology (ASH) ITP guidelines recommend that the initial treatment of children should be based on an assessment of clinical symptoms rather than the degree of thrombocytopenia and that short courses of corticosteroids should be prescribed to children requiring initial medication treatment. Retrospective review evaluating the treatment of newly diagnosed children with ITP has demonstrated that management continues to be based on the platelet count, with high use of IV immunoglobulin, which results in overuse of medications and high rates of inpatient hospitalizations and medical visits for the administration and management of side effects. To improve adherence to ASH guidelines, the ITP Consortium of North America implemented a clinical care pathway as a multicenter quality improvement initiative. Retrospective data (11 centers; n = 284) were collected before implementation and compared to postimplementation data (12 centers; n = 266). With implementation of the clinical pathway, documentation of a bleeding score for children at diagnosis increased from 1% (3/284) to 95% (253/266). At diagnosis, initial treatment with ITP-directed medications decreased in children with no or mild bleeding symptoms (62% [177/284] vs 31% [83/266]; P< .0001). IV immunoglobulin use reduced from 51% (145/284) to 15% (41/266; P< .0001). With implementation of the pathway, clinical outcomes were comparable with no increase in inpatient hospitalizations or bleeding events. Implementation of a clinical care pathway for a rare condition increases adherence to evidence-based guidelines and is feasible to implement across multiple centers.
Source: Blood Advances
Authors: Elizabeth Gunn, Pablo A. Angulo, Sherif M. Badawy, Monica Davini, Hannah Elkus, Kirsty Hillier, Shipra Kaicker, Jeffrey Lebensburger, Neeti Luke, Kathryn E. Scott, Taizo A. Nakano, Allison Remiker, Stacey Rifkin-Zenenberg, Corinna L. Schultz, Taylah Buissereth, Kathryn Carrier, Jeffrey Durney, Anthony Dekermanji, Rachael F. Grace
Institutions: Children's Healthcare of Atlanta, Banner Health, Northwestern University, Lurie Children's Hospital, Akron Children's Hospital, NYU Langone Health, New York University, Weill Cornell Medicine, University of Alabama at Birmingham, Children's Minnesota, University of Minnesota Children's Hospital, SUNY Upstate Medical University, Children's Hospital Colorado, University of Colorado Anschutz, Medical College of Wisconsin, Hackensack University Medical Center, Nemours Children's Health System, Harvard University, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W7127981609