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Ascorbate elastomer-coated ePTFE grafts inhibit neointimal hyperplasia and enhance vascular healing

Year: 2025
Type: article
Abstract: 19.9 %, p < 0.005). POCA-Grafts showed a 1.6-fold increase in endothelial cell coverage and significantly reduced leukocyte and macrophage infiltration compared to uncoated ePTFE grafts, particularly in female animals. These results suggest that the POCA coating enhances graft biocompatibility by promoting endothelialization and reducing inflammation, thereby inhibiting neointimal hyperplasia and improving graft patency. Overall, these results highlight the therapeutic potential of an ascorbate-functionalized poly(diol-co-citrate) elastomer for vascular applications and support future evaluation in large animal models.
DOI: 10.1016/j.bioactmat.2025.10.014
Authors: Lu Yu, Emily R. Newton, David C. Gillis, Brian C. Cooley, Kui Sun, Brooke R. Dandurand, Robin Siletzky, Nick D. Tsihlis, Melina R. Kibbe
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,200
Funders: U.S. Department of Veterans Affairs, Office of Research and Development, Health Services Research and Development, University of Virginia, Fu Foundation School of Engineering and Applied Science, School of Medicine, University of Virginia
OpenAlex ID: W4417117143
FWCI:
Cites: 99
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Related to: 10