Work

Bacteriophage-derived depolymerases as antimicrobial synergists: A strategy to overcome resistance

Year: 2026

Type: article

Abstract: Upon infection, bacteria form polysaccharides barriers, such as capsular polysaccharide (CPS), exopolysaccharide (EPS) and lipopolysaccharide (LPS). The barrier hinders antibiotic penetration and host immune clearance, exacerbating antimicrobial resistance crisis. Bacteriophages (phages), natural viruses that can specifically infect and kill bacteria, have evolved depolymerase to degrade the polysaccharides. This review evaluates the primary therapeutic value of depolymerases as synergists to existing therapies, systematically detailing their potential to enhance antibiotic efficacy, improve phage therapy, and augment host immunity. We further integrate an evolutionary perspective to analyze likely adaptive responses and potential strategies to eradicate resistance. Finally, the discussion addresses formulation challenges and future prospects for the clinical translation of depolymerase-based synergistic therapies.

Source: BioScience Trends

DOI: 10.5582/bst.2026.01003

Authors: Shuhong Han, David H Yang, Jiayin Shen, Hongzhou Lu

Institutions: Southern University of Science and Technology, Shenzhen Third People’s Hospital, University of California, Los Angeles

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Ecology

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, National Science and Technology Major Project