Work

Association between monocyte to high-density lipoprotein cholesterol ratio and stroke prevalence in American adults: A cross-sectional NHANES Study

Year: 2026

Type: article

Abstract: BACKGROUND: The monocyte to high-density lipoprotein ratio (MHR) is a novel biomarker reflecting systemic inflammation and lipid metabolism disturbances, providing insights into the pathophysiological mechanisms of stroke development. While prior research has established a connection between MHR and cardiovascular outcomes, its association with stroke has yet to be conclusively validated in large-scale, population-based cohorts. METHODS: Data from the 1999-2018 National Health and Nutrition Examination Survey (NHANES) was used for the analysis. Subgroup analyses evaluated association robustness across demographic strata.The study assessed the link between MHR and stroke prevalence using restricted cubic spline regression (RCS) methods. Adjustments were made for demographic characteristics, lifestyle factors, and clinical confounding variables.Subgroup and sensitivity analyses evaluated the robustness of observed associations. RESULTS: Among the 28,238 participants included in the study, 805 individuals (2.08%) experienced a stroke. A comprehensive logistic regression analysis demonstrated that each standard deviation (SD) increase in MHR was associated with 20% higher odds of stroke (OR = 1.20, 95% CI: 1.08-1.33, P < 0.05). RCS analysis indicated a linear association between MHR and stroke(P > 0.05). Subgroup and sensitivity analyses consistently demonstrated a significant positive association between MHR and stroke. This national, cross-sectional study demonstrated a linear positive correlation between the MHR and stroke, highlighting its potential utility as an indicator. However, the cross-sectional design precludes causal inference, which requires verification by prospective studies.

Source: Journal of Stroke and Cerebrovascular Diseases

DOI: 10.1016/j.jstrokecerebrovasdis.2026.108580

Authors: Jiahui Wang, Guojiang Zheng, Jianhua Xu

Institutions: Jiading District Central Hospital, Shanghai University of Medicine and Health Sciences

Language: English

Topic: Lipoproteins and Cardiovascular Health

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,170