Work

Main characteristic metabolites with xanthine oxidase inhibitory activities from Yunnan Coffea arabica husks

Year: 2026

Type: article

Abstract: -IT-TOF analysis, antioxidant and xanthine oxidase (XO) inhibitory assays. A total of 55 main characteristic compounds were identified and their detailed mass spectrometry cleavage patterns were elucidated. Chlorogenic acid analogs as key bioactive constituents comprised over 66% of the identified phenols, which spontaneously bind to XO, with binding energy ranging from -4.46 to -3.32 kcal/mol. The antioxidant activities of di-substituted chlorogenic acids were significantly higher than those of mono-substituted molecules. Flavonoids from the "husks" with XO inhibitory activities were attributed to the flavone skeleton, in which the presence of a stable chromone group was vital. These results provided novel perspectives for discovery of XO inhibitors from widely discarded natural by-products like coffee "husks".

Source: Food Chemistry X

DOI: 10.1016/j.fochx.2026.103637

Authors: Hong Wang, Li Wan, Yu Wang, Yan Li, Wenli Zhao, Wenjuan Liang

Institution: Yunnan Agricultural University

Language: English

Topic: Coffee research and impacts

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: gold

Estimated APC paid: $2,330

Funders: National Natural Science Foundation of China, Kunming Institute of Botany, Chinese Academy of Sciences