Treatment efficacy prediction model for patients with concurrent allergic rhinitis and laryngopharyngeal reflux
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective To construct and validate a prediction model based on the treatment efficacy of patients with laryngopharyngeal reflux (LPR) and allergic rhinitis (AR), and to provide a quantitative tool for individualized treatment decision-making. Methods A total of 106 AR patients admitted to the hospital from January 2023 to November 2024 were included. They were randomly divided into a training set ( n = 73) and a validation set ( n = 33) at a ratio of 7:3. Independent influencing factors were screened by univariate and multivariate Logistic regression to construct a Nomogram model. The model performance was evaluated using receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA). Results The baseline data of the training set and the validation set were balanced ( p > 0.05). Multivariate analysis showed that BMI, duration of AR, number of allergens, and total serum IgE were independent predictors of treatment efficacy ( p < 0.05). The areas under the ROC curve (AUC) were 0.809 (95% CI: 0.693–0.924) and 0.823 (95% CI: 0.630–1.000) respectively in the training set and validation set, and the calibration curve showed a good fit. Conclusion The constructed Nomogram model can effectively predict the treatment response of patients with AR complicated by LPR and guide clinical stratified intervention.
Source: Frontiers in Medicine
Authors: Pan Xie, Fusen Peng, Zhichao Xiao, Ying Zhang
Institution: Loudi Central Hospital
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W7128031800