Work

USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD

Year: 2026

Type: article

Abstract: . These findings establish USP5-mediated stabilization of CD73 as a central mechanism underlying glycolytic metabolism and osimertinib resistance in LUAD, highlighting the USP5/CD73 pathway as a promising prognostic indicator and therapeutic target for LUAD treatment.

Source: iScience

DOI: 10.1016/j.isci.2026.114916

Authors: Rui Chen, Xin-Hao Han, Zhen Zhang, Xiao-Jian Han, Junping Xie

Institutions: Nanchang University, Second Affiliated Hospital of Nanchang University, Jiangxi Provincial People's Hospital, Nanchang Medical College

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240