Work

Discovery and Optimization of 4-Aminopteridin-7(8 H )-one Derivatives as Potent and Selective mTOR Inhibitors with Favorable Pharmacodynamic and Safety Characteristics

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c03503

Authors: Danyang Wang, Gengwu Li, Jianguang Liu, Mengxin Li, Xudan Peng, Jinfeng Deng, Shujie Zhao, Kang Zou, Xiaohan Zhang, Dan Liu, Micky D. Tortorella, Linping Wu, Shibing Tang

Institutions: Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, Shenyang Pharmaceutical University

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G2643527632, G5529963764, G5710695186, G7641918490, G7840973300

OpenAlex ID: W7128048630

FWCI:

Cites: 46

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