A Clickable Assembly of Enamide‐Functionalized Allylic and Vinyl Sulfonyl Fluorides With Exclusive Selectivity
Year: 2026
Type: article
Abstract: ABSTRACT A practical and efficient method was developed for the selective construction of allylic and vinyl sulfonyl fluorides. This protocol features mild reaction conditions, modular access to valuable “clickable” handles in moderate to excellent yields (60%–99%), and a broad substrate scope with functional group compatibility. Subsequently, the resulting sulfonyl fluorides were further diversified via sulfur fluoride exchange (SuFEx) reactions to produce sulfonates, sulfonamide, and enabled the late‐stage modification of bioactive molecules, showcasing their immediate value for application in chemical biology and drug discovery.
Source: ChemistrySelect
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G2852311056, G4238096855
OpenAlex ID: W7128050835