Work

Structural characterization and hypolipidemic activity of polysaccharides from finger citron

Year: 2026

Type: article

Abstract: In this study, the structural characterization and hypolipidemic activity in vivo of finger citron polysaccharide (FCP) were investigated. The FCP consisted of [→t)-Ara(f)-(1→], [→5)-Ara(f)-(1→], and [→4)-Gal(p)-UA-(1→] with the molecular weight of 46.35 KDa. FCP significantly decreased the levels of total cholesterol (TC), triglyceride (TG), low density cholesterol (LDL-C), phenylpropionate aminotransferase (ALT), and aspartate aminotransferase (AST) and increased the level of high density cholesterol (HDL C) in the serum of mice ( P < 0.05). Besides, FCP could significantly improve the antioxidant enzymes activities and decreased the liver lipid metabolism indexes ( P < 0.05). AMPK/ACC and PPARα/LXRα were used to investigate the hypolipidemic mechanism of FCP, which indicated that FCP could up-regulate the protein and gene levels of AMPK, acetyl-CoA carboxylase(ACC), PPARα and LXRα. This study provides an important basis of FCP for inhibiting the occurrence of metabolic disorders such as hyperlipemia and complications.

Source: Journal of Functional Foods

DOI: 10.1016/j.jff.2026.107185

Authors: Juan-Juan Ma, Xi Xie, Lu-Kai Ma, Qin Wang, Geng-Sheng Xiao, Hui-Fan Liu

Institution: Zhongkai University of Agriculture and Engineering

Language: English

Topic: Natural Products and Biological Research

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800