Work

Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia

Year: 2026

Type: article

Abstract: We related early insulin resistance-associated peripheral factors with brain glucose measured by 13 C magnetic resonance spectroscopy during acute hyperglycemia in young, healthy adults with and without obesity. Plasma amino acids including aromatic amino acids and glucagon were higher in obesity during acute hyperglycemia. There were negative correlations between aromatic amino acids and glucagon with the change in brain glucose. These findings may be related to brain oxidative stress and neurotransmitter synthesis in obesity.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00463.2025

Authors: Brooke C. Matson, Felona Gunawan, Douglas L. Rothman, Graeme F. Mason, Olga Ilkayeva, Christopher B. Newgard, Janice J. Hwang

Institutions: University of North Carolina at Chapel Hill, Yale University, Duke University

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Yale University, University of Texas Southwestern Medical Center, Endocrine Fellows Foundation, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke

Awards: G1236451951, G1457647595, G4348250162, G4975162751, Comprehensive, Cross Platform-Validated 13C Flux Measures of Intra-and Inter-tissue Metabolism, G6558549469, 13C MRS Studies of Brain Mitochondrial Metabolism in Insulin Resistance, G910108439, G950284202

OpenAlex ID: W7128064559

FWCI:

Cites: 38

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