Work

Nano-Enabled Broadband Near-Infrared Light Boosts Secondary Metabolite Production for Nanoliposomal Delivery toward Glioblastoma Applications

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Ursolic acid (UA) and rosmarinic acid (RA) are secondary metabolites obtained from Mesona procumbens Hemsl. and exhibit potent antitumor properties. Using Gd 3 (Sc,Al) 2 Ga 3 O 12:Cr 3+ near-infrared phosphor-converted light-emitting diodes (NIR pc-LEDs), this study optimized UA and RA production by 16 and 48%, respectively. Liposomal encapsulation generated a nanoscale delivery system (RA/UA@LP, 290 ± 14 nm), improving their dispersity and establishing a nanoliposomal platform with in vitro BBB-crossing potential for brain-targeted delivery. Experiments revealed that in vitro, RA/UA@LP reduced U87MG glioblastoma cell viability to 49%, with no toxicity in SVGp12 cells. In vivo analysis using a heterotopic glioblastoma model (subcutaneous transplantation) showed that RA/UA@LP decreased tumor fluorescence radiance by 78% after 5 weeks, outperforming nonencapsulated RA/UA by 71%. This model facilitates noninvasive tumor monitoring while maintaining clinical relevance. The integration of NIR pc-LEDs and nanocarrier technology enhances therapeutic compound production and efficacy, advancing agriculture and oncology.

Source: ACS Applied Nano Materials

DOI: 10.1021/acsanm.5c05626