Predictive Value of Cardiac Troponin Combined with p-SOFA Score in Sepsis Children with PCIS ≥ 70
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: To analyze the prediction value of cardiac troponin I (cTnI), cardiac troponin T (cTnT), and the pediatric Sequential Organ Failure Assessment (p-SOFA) score in children with severe sepsis. Methods: 80 children with sepsis [Pediatric Critical Illness Score (PCIS) ≥ 70] were selected and categorized into severe sepsis group (PCIS score of 71– 80, n=52) and non-severe sepsis group (PCIS score > 80, n=28) according to the PCIS score, and 50 non-septic children admitted to our hospital during the same period were selected as non-sepsis group. The value of cTnT, cTnI, p-SOFA and their combination in predicting the occurrence of severe sepsis was analyzed. The relationship between the each indicator and poor prognosis of children with severe sepsis was analyzed. Results: The plotted ROC curves revealed that the AUC values for predicting the occurrence of severe sepsis were as follows: cTnT: 0.897 (95% CI: 0.787– 0.972), cTnI: 0.881 (95% CI: 0.788– 0.975), p-SOFA: 0.795 (95% CI: 0.701– 0.890), and their combination: 0.935 (95% CI: 0.883– 0.988). Regression analysis showed that cTnT, cTnI, p-SOFA score, CRP and PCT levels were significantly associated with the poor prognosis of children with severe sepsis ( p < 0.01). Conclusion: cTnI, cTnT, and p-SOFA are closely related to the inflammatory response in children with severe sepsis, and the combination of the three indicators can effectively assess the severity of sepsis. The elevated levels of cTnI and cTnT and increased p-SOFA score are closely associated with the poor prognosis of children with severe sepsis. Keywords: cardiac troponin I, cardiac troponin T, pediatric sequential organ failure assessment score, severe sepsis, prognosis
DOI: 10.2147/ijgm.s562566
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,836
OpenAlex ID: W7128092299