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Immuno‐Packed T‐Cell‐Fusogenic Liposome Empowers Adoptive T Cell Therapy for Solid Tumor Treatment (Adv. Mater. 8/2026)

Year: 2026

Type: article

Abstract: IMPACTFUL Adoptive T Cell Therapy In their Research Article (DOI: 10.1002/adma.202510842), Mingqiang Li, Yu Tao, Haochen Yao, and co-workers present an immuno-packed T-cell-fusogenic liposome (IMPACTFUL) that enables T-cell engineering through membrane fusion. This approach facilitates concurrent targeting across multiple cellular compartments, including the cell membrane and cytoplasm. By leveraging this dual-targeting strategy, T cells acquire enhanced functionalities, such as improved tumor infiltration, overcoming immune tolerance, and reversing the immunosuppressive tumor microenvironment. This versatile platform offers a promising approach to enhance the therapeutic efficacy of adoptive T cell therapies for solid tumors.

Source: Advanced Materials

DOI: 10.1002/adma.72147

Authors: Chunxiong Zheng, Ke Yi, Yongkang Du, Qingguo Zhong, Huimin Kong, Haixia Wang, Enguo Ju, Yeh‐Hsing Lao, Xi Xie, Haochen Yao, Yu Tao, Mingqiang Li

Institutions: Sun Yat-sen University, South China Normal University, Third Affiliated Hospital of Sun Yat-sen University, University at Buffalo, State University of New York, State Key Laboratory of Optoelectronic Materials and Technology, Jilin University

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7128162571

FWCI: 2.632

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Cited by: 1

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