Work

Falls predict faster progression to Alzheimer's dementia

Year: 2026

Type: article

Abstract: INTRODUCTION: [CDR] = 0). Differentiating trajectories of healthy aging and preclinical AD is challenging as both are associated with age-related impairments (e.g., falls). METHODS: Longitudinal cohort study. We monitored falls for 1 year among 125 CDR 0 older adults and assessed preclinical AD status (amyloid). We continued to evaluate CDR annually (median 10 years). The cohort was grouped: Preclinical AD-Fall-, Preclinical AD-Fall+, Preclinical AD+Fall-, and Preclinical AD+Fall+. Survival analysis examined time to progression to CDR 1 (mild dementia) by group. RESULTS: Participants were 74 years (mean) at baseline, 62% female, 96% White. Preclinical AD+Fall+ progressed to CDR 1 most rapidly. Preclinical AD-Fall- progressed least quickly. Preclinical AD+Fall- and Preclinical AD-Fall+ had similar progression rates. DISCUSSION: Falls may associate with faster progression of AD dementia, potentially reflecting motor and gait dysfunction intrinsic to disease progression.

Source: Alzheimer s & Dementia

DOI: 10.1002/alz.71177