Work

Practitioner Protocol for the Photoreduction of [ 14 C]CO 2 to [ 14 C]CO and Its Application to the Aminocarbonylation of an Aryl Iodide

Year: 2026

Type: article

Abstract: ABSTRACT Carbon‐14 labeling is fundamentally important for supporting the development of new agrochemicals and pharmaceuticals. Given its critical importance, continued innovation in technologies and methodologies for radiolabeling should be strongly encouraged to better support the radiochemistry community. However, a persistent gap often exists between technological breakthroughs and their broad adoption by the scientific community. To help bridge this gap, we have developed a Practitioner Protocol detailing a recent method from our laboratory. This protocol describes how to produce 14 C‐labeled carbon monoxide ([ 14 C]CO) directly from the universal precursor, [ 14 C]carbon dioxide ([ 14 C]CO 2 ). We hope this protocol will facilitate the adoption and implementation of this technology in other radiochemistry laboratories, thereby enhancing radiolabeling capabilities across the field.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/jlcr.70021