Work

Flt3L from interfollicular stroma maintains resident dendritic cells

Year: 2026

Type: article

Abstract: Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1) + fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting stromal cells as key regulators of immunity.

Source: Trends in Immunology

DOI: 10.1016/j.it.2026.01.010

Authors: Arpa Aintablian, Ayse N. Kilinc, Angela Riedel

Institutions: University of Würzburg, Universitätsklinikum Würzburg

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030