Work

COMIP‐001: A clinical 13‐antibody, 12‐color flow cytometry panel for optimized immunophenotyping of T/ NK cells in human leukemia and lymphoma diagnostics

Year: 2026

Type: article

Abstract: The objective of this 12-color/13-antibody single-tube panel is to assist in the diagnosis of T/NK-cell leukemias and lymphomas. In the clinical setting, the absence of a standardized T/NK-cell panel limits inter-laboratory data comparability, contributes to diagnostic variability, and results in redundant efforts across laboratories to design and validate panels for flow cytometry. Developing and promoting a panel that allows for rapid and fairly comprehensive labeling of surface T/NK-cell markers, including the anti-T-cell receptor β-chain constant region 1 (TRBC1) antibody, will streamline the workflow by establishing a standard immunophenotyping T/NK-cell panel for detecting neoplastic T/NK cells and lay the foundation for future COMIPs.

Source: Cytometry Part B Clinical Cytometry

DOI: 10.1002/cytob.70015

Authors: Nicole So, Sara Monaghan, Katelynn Davis, Grant Bullock, Wendy Shallenberger, Ahmad Al‐Attar