Year: 2026
Type: article
Abstract: Wound healing is a complex and dynamic biological process involving multiple phases, including inflammation, proliferation, and tissue remodeling. Despite significant advances in therapeutic approaches, conventional wound healing treatments often suffer from limitations such as poor bioavailability of drugs, inadequate moisture retention, uncontrolled release profiles, and delayed tissue regeneration. To overcome these challenges, drug-loaded nanocrystals were incorporated into an alginate-based hydrogel matrix to develop a biocompatible and sustained-release wound dressing. Emodin, a natural anthraquinone compound with potent anti-inflammatory, antioxidant, and antimicrobial properties, was used as the therapeutic agent. The combination of emodin nanocrystals with the alginate hydrogel resulted in a synergistic effect, providing enhanced drug stability, controlled release, and accelerated tissue regeneration. The developed NCs-hydrogel composite demonstrates significant potential as an advanced wound dressing material, offering an effective and biocompatible platform for promoting rapid wound healing.
Source: Macromolecular Bioscience
Institutions: Indian Institute of Technology BHU, Banaras Hindu University
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G454887161
OpenAlex ID: W7128388965