Work

Synthesis, Spectral Properties, and Noncovalent Bioconjugation of 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene with Purine Nucleobases

Year: 2025

Type: article

Abstract: A preparative method has been developed for the synthesis of 1,3,5-trinitro-2-(prop-2-yn-1-yloxy)benzene in 79% yield under mild conditions from commercially available initial compounds. The structure of the title compound has been confirmed by 1 H NMR spectroscopy. 1,3,5-Trinitro-2-(prop-2-yn-1-yloxy)benzene has been found to form noncovalent bioconjugates with DNA molecules and deoxynucleoside triphosphates. The resulting bioconjugates can be involved in click reactions with azide dyes.

Source: Russian Journal of Organic Chemistry

DOI: 10.1134/s107042802560514x

Authors: D. A. Kazantsev, M. V. Bytov, O. S. Zaitseva

Institutions: Russian Academy of Sciences, Ural Branch of the Russian Academy of Sciences

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funder: Russian Science Foundation

OpenAlex ID: W7128404141