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Author response: Accessibility of the unstructured α-tubulin C-terminal tail is controlled by microtubule lattice conformation

Year: 2026

Type: peer-review

Abstract: Three newly developed biosensors demonstrate that the C-terminal tail of α-tubulin does not freely extend from the microtubule surface as widely thought, but rather is inaccessible along most microtubules in cells.

DOI: 10.7554/elife.109308.3.sa4

Authors: Takashi Hotta, Morgan L Pimm, Ezekiel C Thomas, Yang Yue, Patrick DeLear, Lynne Blasius, Michael A Cianfrocco, Morgan E DeSantis, Ryota Horiuchi, Takumi Higaki, David Sept, Ryoma Ohi, Kristen J Verhey

Institutions: University of Michigan, Kumamoto University

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W7128424321

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