Work

Photoredox‐Catalyzed Decarboxylative Cascade Cyclization of NHPI Esters With Isocyanides: Access to 2‐Alkylbenzothiazoles/2‐Alkylbenzoselenazoles

Year: 2026

Type: article

Abstract: ABSTRACT A metal‐free photoredox catalysis enabling a decarboxylative radical cascade cyclization for the efficient synthesis of 2‐alkylbenzothiazoles/2‐alkylbenzoselenazoles is described. This protocol utilizes alkyl N ‐hydroxyphthalimide (NHPI) esters and 2‐isocyanaryl thioethers/selenoethers as the substrates, and the transformation proceeds through a photoredox‐catalyzed, radical addition‐triggered cascade cyclization. This method features mild conditions, excellent functional group tolerance, and a broad substrate scope encompassing primary, secondary, and tertiary alkyl radicals, providing a versatile entry to these valuable heterocycles.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.70325

Authors: Dan Liu, Kaiwen Yi, Shichao Yang, Huanfeng Jiang, Wanqing Wu

Institutions: State Key Laboratory of Luminescent Materials and Devices, South China University of Technology

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Natural Science Foundation of Guangdong Province, Guangzhou Municipal Science and Technology Bureau

Awards: G6014490706, G728042799