Work

Telomeres and Telomerase

Year: 2026

Type: preprint

Abstract: Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution. This volume presents an integrated collection of perspectives spanning telomere architecture, replication dynamics, telomere-driven genome instability, and telomere maintenance by telomerase and Alternative Lengthening of Telomeres (ALT), while also charting new therapeutic directions grounded in telomere biology. Drawing on molecular, structural, organismal, and clinical research, this collection showcases a field in rapid motion, reshaping our view of regeneration, aging, and disease.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a041972

Authors: Julia Promisel Cooper, Eros Lazzerini Denchi, Joachim Lingner, Hilda A. Pickett

Institutions: University of Colorado Anschutz, National Institutes of Health, National Cancer Institute, École Polytechnique Fédérale de Lausanne, The University of Sydney, Children's Medical Research Institute

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7128424801

Cites: 22

Cited by: 1

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