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Screen-Printed Electrode Modified with Silver Nanoparticles (AgNP)─Polydopamine (PDA)─Reduced Graphene Oxide (RGO) Nanocomposite as a Sensor for Uric Acid

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A uric acid (UA) sensor was developed through the modification of carbon screen-printed electrodes (SPE) with a nanocomposite of silver nanoparticles (AgNP), polydopamine (PDA), and reduced graphene oxide (RGO). The AgNP-PDA-RGO nanocomposite was characterized by ATR-FTIR, UV–vis, Raman, and SEM–EDX to confirm the synthesis of the nanocomposite. Electrocatalytic activity was investigated by measuring specific capacitance and peak current using cyclic voltammetry using a Fe(CN) 6 –3/–4 probe. Analytical performance of the AgNP-PDA-RGO modified SPE for UA was investigated by using differential pulse voltammetry in acetate buffer (pH 4.5). Two linear ranges from 20–100 μM and 200–1000 μM were established with a limit of detection of 1.23 μM. The UA signal was repeatable (relative standard deviation (RSD) = 5.00%, n = 10) on a single modified electrode and reproducible across multiple electrodes (RSD = 0.95%, n = 3), and the signal was stable after 28 days (only 0.41% change from initial signal, n = 3). The AgNP-PDA-RGO sensor was also used for the measurement of UA in lab-prepared urine samples and tested in the presence of organic interferents such as ascorbic acid, dopamine, and glucose.

Source: ACS Omega

DOI: 10.1021/acsomega.5c08454

Authors: Francis Angelo Dominguez, Rowell Jones Matabilas, Jan Pierre Rizalino Montecillo, Allan Christopher Yago

Institution: University of the Philippines Diliman

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935