Enhanced spinosad production in Saccharopolyspora spinosa by employing mannose as an extracellular carbon reservoir and optimizing acetyl-CoA supply pathway
Year: 2026
Type: article
Abstract: and related actinomycetes. Critically, the identification of mannose as the preferred carbon source not only directly enhanced precursor supply but also proved pivotal in redirecting metabolic flux through the glycolytic pathway, thereby generating elevated levels of acetyl-CoA. The acetyl-CoA pathway engineering strategy developed here can be readily adapted to enhance the production of other high-value polyketides.
Authors: Zirong Zhu, Qin Zhao, Yan Zhu, Ling Shuai, Jun Li, Qing Liu, Xirong Liu, Shanrui Wang, Duo Jin, Zirui Dai, Liqiu Xia, Hongrong Liu, Jie Rang
Institution: Hunan Normal University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W7128428299