Work

Minimal intraoperative anticoagulation strategy for lung transplantation with preoperative heparin-induced thrombocytopenia

Year: 2026

Type: article

Abstract: Heparin-induced thrombocytopenia (HIT) in patients on mechanical circulatory support (MCS) prior to lung transplantation poses a unique challenge of balancing thrombotic versus hemorrhagic complications. An alternative method of anticoagulation is bivalirudin, offering advantages of rapid titration and a short half-life. We present 2 cases of patients on MCS who developed HIT and were anticoagulated with bivalirudin preoperatively. Contingent on whether additional cannulation was required at the time of lung transplantation, bivalirudin was held either at incision or after cannulation. Both patients were successfully transplanted without coagulopathic complications.

Source: JHLT Open

DOI: 10.1016/j.jhlto.2026.100517

Authors: Neelesh Bagrodia, Ammu V. Alvarez, Doug A. Gouchoe, Bryan A. Whitson, Matthew C. Henn, Kukbin Choi

Institutions: The Ohio State University Wexner Medical Center, The Ohio State University

Language: English

Topic: Heparin-Induced Thrombocytopenia and Thrombosis

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500