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Synthesis of Novel USP1 Inhibitors and Their Uses in Treatment of USP1 Related Diseases

Year: 2026

Type: editorial

Abstract: Ubiquitin-specific protease 1 (USP1) is a member of the deubiquitinating enzyme family that modulates the stability and biological activity of target proteins through the removal of ubiquitin modifications, thereby contributing to tumor development and resistance to anticancer therapies. This patent summary focuses on the design and optimization of a class of small-molecule inhibitors that exhibit high potency and selectivity toward USP1.

Source: ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.6c00031

Authors: Haofeng Shi, Steven H. Liang

Institutions: Emory University, Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W7128431285

Cites: 9

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