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E3 ubiquitin ligase COP1-mediated GSK3β degradation activates β-catenin signaling to facilitate colorectal cancer cell proliferation

Year: 2026

Type: article

Abstract: Colorectal cancer (CRC) remains one of the most prevalent and lethal malignancies worldwide, imposing a substantial burden on global healthcare systems [1].Despite advances in early detection and therapeutic strategies, the prognosis for patients with advanced or metastatic CRC remains poor, highlighting the urgent need to unravel the underlying molecular mechanisms driving CRC initiation and progression.COP1 (constitutive photomorphogenic 1, also known as RFWD2) was initially found in Arabidopsis as a regulator of photomorphogenesis [2].COP1 functions as a

Source: Acta Biochimica et Biophysica Sinica

DOI: 10.3724/abbs.2026023

Authors: Dakui Luo, Kangjunjie Wang, Yufei Yang, Qingguo Li, Xinxiang Li

Institutions: Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Tongji University, Shanghai Pulmonary Hospital

Language: English

Topic: Wnt/β-catenin signaling in development and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7128434186

FWCI:

Cites: 8

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