Work

Pure large-cell neuroendocrine carcinoma of the bladder with pelvic organ invasion: A case report

Year: 2026

Type: article

Abstract: Large-cell neuroendocrine carcinoma (LCNEC) of the bladder is a rare, high-grade malignancy with aggressive behavior. We report a 69-year-old woman presenting with recurrent macroscopic hematuria. Imaging revealed a large tumor of the bladder floor involving the right ureterovesical junction, with local extension to adjacent pelvic organs but no nodal or distant metastases. Histology and immunohistochemistry confirmed pure LCNEC. She received four cycles of carboplatin-etoposide, followed by anterior pelvic exenteration with ileal conduit diversion. Postoperative recovery was uneventful, and early follow-up showed no recurrence. The case illustrates the complexity of managing locally advanced bladder LCNEC and supports individualized multimodal therapy.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2026.103371

Authors: Sami Chebbi, Houssem Bel Hadj Alouane, Mohamed Amine Oueslati, Raoueh Hedhli, Ehsen Ben Brahim, Sami Ben Rhouma

Institutions: Habib hospital Thameur, Tunis El Manar University

Language: English

Topic: Urinary and Genital Oncology Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,160