Work

Ionic‐liquid‐promoted dual hydrogen‐bond activation strategy enabling the synthesis of diverse 2‐pyridone‐fused uracils

Year: 2026

Type: article

Abstract: The synthesis of diverse 2‐pyridone‐fused uracils has been accomplished using the ionic liquid [bmim]BF 4 as a dual hydrogen‐bond (HB) activator. A [4 + 2] annulation–dehydration cascade reaction between 6‐methyluracil‐5‐carbaldehydes and isocyanates was promoted through a HB‐mediated strategy based on non‐covalent interactions (NCIs). This protocol provides an operationally simple procedure that eliminates the use of strong bases, enabling straightforward access to structurally intriguing 2‐pyridone‐fused uracils—valuable scaffolds with promising potential in drug discovery.

Source: Bulletin of the Korean Chemical Society

DOI: 10.1002/bkcs.70097

Authors: Yeong Shin Ji, So Won Youn

Institution: Hanyang University

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: National Research Foundation, National Research Foundation of Korea, Ministry of Science and ICT, South Korea

Awards: G1243754147, G1915845685, G5692121107, G571812284