Prognostic value of resting high-frequency QRS for clinical outcomes after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: A prospective cohort study
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objectives: The prognostic value of resting high-frequency QRS (HFQRS) for major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction remains inconclusive. This study aimed to investigate the value of resting HFQRS in evaluating the clinical prognosis of patients with acute myocardial infarction (AMI) after emergency PCI. Methods: In this single-center, prospective cohort study (registration no. ChiCTR2600116159), we enrolled 121 patients with AMI who were treated with emergency PCI in the First Affiliated Hospital of the University of Science and Technology of China. The study period spanned from September 2023 to October 2024. Patients were divided into HFQRS positive group (≥3 ischemic leads, n = 67) and negative group (≤2 ischemic leads, n = 54) according to HFQRS signals within 24 hours post-PCI. The baseline data, laboratory indicators, and incidence of MACE were collected. Univariate analysis and multivariate Cox proportional hazards regression were applied to identify factors influencing poor prognosis in patients with AMI after emergency PCI. Results: The positive group showed significantly higher age, left atrial/ventricular diameters, N-terminal pro B-type natriuretic peptide levels, and proportion of multivessel coronary lesions (all P < 0.05), but lower prevalence of diabetes, lower level of low-density lipoprotein cholesterol, and hemoglobin (all P < 0.05). During follow-up (median 12 months), the MACE incidence was higher in the positive group (55.2% versus 35.2%, P = 0.028), especially for recurrent angina (32.8% versus 11.1%, P = 0.005). Cox analysis showed that the number of ischemic leads in HFQRS was an independent risk factor for MACE (hazard ratio = 1.105, 95% confidence interval: 1.006–1.214, P = 0.037). Conclusions: Resting HFQRS is an independent predictor of MACE in patients with AMI after PCI, serving as a promising noninvasive tool for prognostic evaluation.
Source: Asian Heart Journal
Institution: University of Science and Technology of China
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7128436817