Work

Pharmacomultiomics suggests new off-targets for targeted anti-cancer agents

Year: 2026

Type: article

Abstract: • Multi-omics of 900+ cell lines links drug sensitivity to 6 omics layers • EGFR-TKIs show novel epigenetic and metabolic off-target effects • Butyrylcarnitine serves as a potential biomarker for ibrutinib sensitivity • KPT-9274 disrupts CoA metabolism in addition to NAMPT/PAK4 inhibition • NAMPT upregulation contributes to KPT-9274 resistance

Source: Journal of Pharmaceutical Analysis

DOI: 10.1016/j.jpha.2026.101580

Authors: Xuan Linh Mai, Chae-Young Lee, Eunbyul Cho, Sunghyouk Park, Hyuk Nam Kwon

Institutions: Seoul National University, University of Ulsan

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Computational Theory and Mathematics

Field: Computer Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950