Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment
Year: 2026
Type: article
Abstract: Digestive diseases comprise a diverse range of illnesses, which are prevalent worldwide and represent an important health issue. This is particularly relevant for the impact of metabolic-associated steatotic liver disease (MASLD) due to its close association with the obesity pandemic, contributing to the escalation of MASLD as the most common form of chronic liver disease, and the main cause of liver cancer. Not only MASLD reflects the deterioration of liver health, but also has far-reaching consequences for the development of extrahepatic digestive diseases. Along with progression of liver and digestive diseases to liver, colorectal and pancreatic cancer, the onset of inflammatory diseases of the digestive tract, drug-induced liver injury, and cholestasis, the overall impact of these hepatic and digestive diseases is expected to rise in the future and hence merits the attention of clinical and translational research to increase our understanding of the pathogenic mechanisms underlying these disorders in order to improve the diagnosis, management and treatment. With this goal in mind, the current collaborative review gathers experts in a wide range of liver and digestive diseases to provide an up-to-date overview of the mechanisms of disease and identify novel strategies for the improvement of these important health issues.
Authors: Ina Bergheim, Jean Francois Cadranel, Jianguo Chen, Wenxing Ding, Robert Eferl, Carmen Garcia-Ruiz, Hartmut Jaeschke, Firouzeh Kazerouni, Amedeo Lonardo, Derek A. Mann, Nahum Méndez-Sánchez, Camelia Mokhtari, Han Moshage, Chiara Raggi, Pavel Strnad, Oren Tirosh, Honoré Tegwende Zougmore, Jose C Fernandez-Checa
Institutions: University of Vienna, Centre Hospitalier Laennec, University of Kansas Medical Center, Medical University of Vienna, Centro de Investigación Biomédica en Red, Institut d'Investigacions Biomèdiques de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Azienda Ospedaliero-Universitaria di Modena, Newcastle University, Hospital Médica Sur, Universidad Nacional Autónoma de México, University Medical Center Groningen, University of Groningen, University of Florence, Universitätsklinikum Aachen, Hebrew University of Jerusalem, University of Southern California, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7128443489