Work

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Year: 2026

Type: article

Abstract: Parallel to their roles in regulating receptor activation, mounting evidence suggests that monoamines are involved in protein post-translational modification, which regulates the physiological function of the nervous system and various pathophysiologically relevant conditions. These modifications, primarily including serotonylation, dopaminylation, and histaminylation, occur on both histone and non-histone proteins, thereby modulating gene transcription and protein function. This review comprehensively summarizes the types of monoaminylation, the catalytic enzymes and molecular mechanisms, and the corresponding monoamine transporters. Furthermore, we categorize and discuss the roles of monoaminylation across the human body in health and disease, highlighting their functional implications and therapeutic potential. We emphasize the need for precise methodologies to modulate monoamine levels in the context of pathological processes across various diseases. Finally, we outline persistent challenges in the field and suggest promising directions for future research, aiming to facilitate both mechanistic insight and translational applications.

Source: Advanced Science

DOI: 10.1002/advs.202520653

Authors: Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang

Institutions: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Inner Mongolia Medical University

Language: English

Topic: Cancer-related gene regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730