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TNF-⍺-mediated myeloid-instructed CD14+CD4+ T cells are associated with poor survival in lung adenocarcinoma

Year: 2026

Type: article

Abstract: T cells. These findings uncover a TNF-⍺-mediated mechanism of immunosuppression in the TME and highlight aberrant myeloid-T cell interactions as contributors to NSCLC progression.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2026.102593

Authors: Claire Marceaux, Ilariya Tarasova, Daniel Batey, Kenta Yokote, Velimir Gayevskiy, Reema Jain, Marina Leiwe, Laurie Choux, Lucy Riley, Nina Tubau Ribera, Edward Yang, Jack Hywood, Michael Christie, Phillip Antippa, Terence P. Speed, Kelly L. Rogers, Belinda Phipson, Marie-Liesse Asselin-Labat

Institutions: Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, The University of Melbourne

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,620

Funders: Victorian Cancer Agency, Australian Cancer Research Foundation, State Government of Victoria, Kinghorn Foundation, National Health and Medical Research Council

Awards: Statistical methods for analysing single cell data applied to kidney organoids, Effect of DNA damaging agents on the lung immune microenvironment and the initiation of lung cancer

OpenAlex ID: W7128443667

FWCI:

Cites: 71

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