Work

Semaphorins: from CD8⁺ T cells to cancer immunotherapy

Year: 2026

Type: article

Abstract: Semaphorins were initially identified as axon guidance molecules in the nervous system, where they transmit repulsive signals to restrict axonal growth by regulating the dynamics of growth cone cytoskeletal structures. Subsequent studies have demonstrated that semaphorin signaling can restrict the migration of CD8⁺ T cell precursors driven by chemokines, thereby maintaining the corticomedullary structure of the thymus. In recent years, increasing evidence has revealed that semaphorins and their receptors (such as plexins and neuropilins) play critical roles in the lymph node homing and activation of CD8⁺ T cells, as well as in their migration and effector functions within the tumor microenvironment. This review summarizes recent advances in understanding the roles of semaphorins and their receptors in CD8⁺ T cell development, migration, and function, highlighting their potential as targets for cancer immunotherapy.

Source: Biomarker Research

DOI: 10.1186/s40364-026-00903-5

Authors: Zhiying Liu, Yi Wu, Peiqi Xu, Huaxi Xu, Kai Yin, Shengjun Wang

Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University

Language: English

Topic: Axon Guidance and Neuronal Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890