Work

LINC01857 promotes clear cell renal cell carcinoma progression by scaffolding DNMT1 to suppress WIF1 expression

Year: 2026

Type: article

Abstract: The long intergenic non-coding RNA LINC01857 has been implicated in various human malignancies; however, its specific role in clear cell renal cell carcinoma (ccRCC) remains unclear. In this study, we report that LINC01857 is markedly upregulated in ccRCC tissues and cell lines. Functionally, LINC01857 knockdown suppressed the proliferation, migration, and invasion of ccRCC cells, whereas its overexpression promoted these malignant phenotypes. Mechanistically, LINC01857 recruits the DNA methyltransferase DNMT1 to the WIF1 promoter, leading to promoter hypermethylation and transcriptional repression of WIF1. This epigenetic repression of WIF1, in turn, activates the Wnt/β-catenin pathway, which contributes to the aggressive behaviors of ccRCC cells.

Source: Scientific Reports

DOI: 10.1038/s41598-026-38828-6

Authors: Wei Xiang, Lei Lyu, Fuxin Zheng, Chuanhua Zhang, Jingdong Yuan

Institutions: Wuhan No.1 Hospital, Huazhong University of Science and Technology

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,690