Work

Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm

Year: 2026

Type: article

Abstract: ABSTRACT Disseminated Lomentospora prolificans infection typically occurs in immunocompromised hosts and is almost universally fatal. We describe a case of L. prolificans native valve infective endocarditis with cerebral mycotic aneurysm after recovery from allogeneic stem cell transplant. The case is notable for minimal immunosuppression at diagnosis, and pathological evidence of infection at sites which looked normal at surgery or by imaging. With early surgery and olorofim the patient survived to 76 days after diagnosis.

Source: Medical Mycology Case Reports

DOI: 10.1016/j.mmcr.2026.100771

Authors: Robert Hand, J. Owen Robinson, Paul Cannell, Robert Larbalestier, Thomas Gliddon, Peter Boan

Institutions: Fiona Stanley Hospital, Royal Perth Hospital, Pathwest Laboratory Medicine, Sir Charles Gairdner Hospital

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650