Work

MRI-Based Differentiation of Tumor Deposits and Lymph Node Metastases in Rectal Cancer: A Systematic Review of Diagnostic Performance

Year: 2026

Type: review

Abstract: Background/Objectives: Preoperative discrimination between tumor deposits (TDs) and lymph node metastases (LNMs) in rectal cancer on MRI is clinically critical but remains challenging. Methods: A systematic review following PRISMA guidelines was conducted, including studies using MRI to differentiate TDs from LNMs with histopathology as reference. Performance metrics such as AUC, sensitivity, and specificity were extracted. Results: Four retrospective studies (n = 344 patients) were included. Morphology-based MRI showed moderate diagnostic accuracy (AUC 0.72–0.76), whereas DCE-MRI and radiomics models demonstrated improved performance (AUC up to 0.86). Combined multiparametric approaches integrating DWI, DCE, and radiomics yielded the highest discriminative values. Conclusions: MRI-based multiparametric models improve discrimination between TDs and LNMs in rectal cancer. Integration of functional and morphologic features may enhance staging precision and guide therapy planning.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm15041390