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Factor XIII Deficiency in a Moroccan Infant: A Case Report of a Rare Bleeding Disorder

Year: 2026

Type: article

Abstract: Factor XIII deficiency (FXIIID) is a rare autosomal recessive hereditary bleeding disorder caused by heterogeneous mutations, leading to potentially life-threatening hemorrhages and early fetal loss. FXIII plays a vital role not only in cross-linking fibrinogen to stabilize clot formation but also in wound healing, angiogenesis, and fetal viability. Diagnosing FXIIID is particularly challenging, as standard coagulation assays typically yield normal results, necessitating specific FXIII testing an additional barrier in resource-limited settings such as developing countries. Early diagnosis is crucial, especially due to the high risk of intracranial bleeding. We report the case of an infant who was admitted for postcirumcision bleeding and was ultimately diagnosed with congenital FXIII deficiency.

Source: Cureus

DOI: 10.7759/cureus.103326

Authors: Khadija Mesbah, Yousra El Boussaadni, Abdallah Oulmaati

Institution: Centre Hospitalier Universitaire Mohammed VI

Language: English

Topic: Blood properties and coagulation

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7128480442