A study on residual elimination of florfenicol in different tissues of Xiushui yellow-feathered black-bone chickens
Year: 2026
Type: article
Abstract: Objective This study aims to investigate the residue depletion patterns of florfenicol in different tissues of Xiushui yellow-feathered black-bone chickens and to determine the withdrawal time of florfenicol in these chickens.The findings will provide a scientific basis for establishing the withdrawal period of antimicrobial drugs in Xiushui yellow-feathered black-bone chickens，thereby ensuring the safety of Xiushui yellow-feathered black-bone chicken products. Method A total of forty-two healthy 160-day-old Xiushui yellow-feathered black-bone chickens were selected.They were administered florfenicol via drinking water at the recommended dosage of 1.5 g/L of 20% florfenicol powder for 5 consecutive days.Samples of muscle，liver，kidney，and skin fat were collected at 0.16，1，3，5，9，15，and 20 days after drug withdrawal.The residues of florfenicol and florfenicol amine in the samples were determined using liquid chromatography-tandem mass spectrometry（LC-MS/MS）.The withdrawal time for florfenicol in various tissues of Xiushui yellow-feathered black-bone chickens was calculated using withdrawal period software（WT 1.4）. Result The half-life and withdrawal time of florfenicol in Xiushui yellow-feathered black-bone chickens were longer than those in ordinary broiler chickens.The withdrawal times for florfenicol soluble powder in muscle，liver，kidney，and skin fat of Xiushui yellow-feathered black-bone chickens were 11.26 days，0 days，0 days，and 17.58 days，respectively. Conclusion To ensure the safety of Xiushui yellow-feathered black-bone chicken products and consumer health，it is recommended that the withdrawal times for florfenicol in Xiushui yellow-feathered black-bone chickens should be greater than 18 days.
DOI: 10.3724/aauj.2026015
Authors: Wen CHEN, Jiayi ZHOU, Ping WAN, Huihui TAO, Wei CHEN, Dawen ZHANG, Qiegen LIAO, Guoping WU
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W7128485160
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