Work

Trends in Mortality Rates From Hemophagocytic Lymphohistiocytosis in the United States From 2010 to 2023

Year: 2026

Type: article

Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a severe, life-threatening condition marked by uncontrolled T-lymphocyte and macrophage-mediated inflammation, usually secondary to an underlying malignancy or infection in adults. It leads to multiorgan failure and death if not promptly recognized and treated; adult secondary HLH carries an overall mortality rate of 57% in an ICU population regardless of treatment. We examined trends in age-adjusted mortality rates from the Centers for Disease Control and Prevention's Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database to further characterize this interesting multinational finding in an otherwise rare disease. Age-adjusted mortality rates (AAMRs) from HLH showed consistent yearly increases, most of which were statistically significant, with an overall 12-fold rise from 2010 to 2023. This trend was mirrored in all census regions and in most demographic categories.

Source: Cureus

DOI: 10.7759/cureus.103346

Authors: James Di Palma-Grisi, Evan Locke, Steffen Kulp, Suraj Pothineni, Harsh Parmar

Institutions: Hackensack University Medical Center, Hackensack Meridian School of Medicine

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7128488705