Work

Exercise FITT-V during pregnancy: dose-dependent reduction in infant cellular lipid content and whole body fat

Year: 2026

Type: article

Abstract: This study was the first to test how specific prenatal exercise dose, i.e., the FITT-V (frequency, intensity, time, type, volume) metrics, could influence the storage of triglycerides in infant adipogenic mesenchymal stem cells (MSCs). Prenatal exercise led to a reduction in infant whole body fat percentage (BF%), which was reflected by lower lipid storage in infant MSCs. Changes in lipid content were observed in offspring born to participants exercising beyond the minimum recommended weekly volume, 450 metabolic equivalent (MET)·min/wk.

Source: Journal of Applied Physiology

DOI: 10.1152/japplphysiol.00939.2025

Authors: Alex Claiborne, Filip Jevtovic, Ericka M. Biagioni, Lindsey Rossa, Caitlyn Ollmann, Donghai Zheng, Cody Strom, Breanna Wisseman, Samantha McDonald, Edward Newton, Steven Mouro, James deVente, George A. Kelley, Joseph A. Houmard, Nicholas T. Broskey, Linda E. May

Institutions: Miami University, Wake Forest University Health Sciences, Wake Forest University, East Carolina University, Quinnipiac University, University of Rhode Island, Illinois State University, Boise State University

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, Thrasher Research Fund, East Carolina University, National Institutes of Health

Awards: G2692417849, ENHANCED by Mom (Enhanced Neonatal Health And Neonatal Cardiovascular Efficiency Developmentally by Mom), Influence of maternal exercise on Infant skeletal muscle and metabolomics, Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell Metabolism, Effect of exercise modality during pregnancy on childhood obesity risk, G9000048954

OpenAlex ID: W7128492914

FWCI: 18.73

Cites: 28

Cited by: 2

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