Work

Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure–associated chronic rhinosinusitis

Year: 2026

Type: article

Abstract: This study identifies a toxin-associated chronic rhinosinusitis endotype, defined by persistent mast cell accumulation, advancing understanding of how environmental exposures may drive chronic airway disease.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci201075

Authors: Xinyu Wang, Yung-An Huang, Anshika Sethi, Christopher Yue, Sydney Brack, Aiswarya Chattuparambil Binoy, Lauren Crowther, Carol Yan, Adam Deconde, Anton Kushnaryov, Andrew Vahabzadeh-Hagh, Jacob Husseman, Maia Little, Allyssa Strohm, Lily Jih, Jonathan J. Lyons, David H. Broide, Taylor A. Doherty

Institutions: VA San Diego Healthcare System, University of California San Diego

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200

Funders: U.S. Department of Veterans Affairs, National Institute of Allergy and Infectious Diseases

Awards: G1545803332, G5740621972, Mentoring patient-oriented researchers in inflammatory airway disease

OpenAlex ID: W7128493420

FWCI: 10.57

Cites: 6

Cited by: 2

Related to: 10