Work

Electrochemical sensor based on a green-synthesized ZnO/CD-MOF/rGO nanocomposite for simultaneous detection of dopamine and uric acid in the presence of ascorbic acid

Year: 2026

Type: article

Abstract: Here, an ultra-selectivity electrochemical sensor was created to measure dopamine (DA) and uric acid (UA) simultaneously. A GCE modified with ZnO nanoparticles and β-cyclodextrin metal-organic framework decorated reduced graphene oxide (ZnO/CD-MOF/rGO/GCE) was successfully fabricated. The biosynthesized algal-based ZnO NPs and CD-MOF were characterized by TGA, FT-IR, XRD, SEM, and EDX. The fabricated electrode displayed good electro-catalytic activity towards oxidation of DA and UA in phosphate buffer solution (PBS) at pH 7.0. Under optimal conditions, the method exhibited a linear response to DA and UA concentrations range of 50 nM - 500 μM, with low limits of detection (S/N = 3) of 4.337 nM and 8.198 nM, respectively. Further, the prepared sensor exhibited desirable reproducibility, longtime stability, and high selectivity, and effectively distinguishing both biomolecules from common interferents. The proposed sensor provides a simplified method to determine DA and UA in biological samples with satisfy recoveries.

Source: Materials Today Communications

DOI: 10.1016/j.mtcomm.2026.114840

Authors: Mohamed Abd-Elsabour, Mortaga M. Abou-Krisha, Abdulrahman G. Alhamzani, Mouslim Messali, Tarek A. Yousef

Institutions: Luxor University, Imam Mohammad ibn Saud Islamic University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $2,830

Funders: Deanship of Scientific Research, Imam Mohammed Ibn Saud Islamic University, Imam Mohammed Ibn Saud Islamic University