Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Post-stroke cognitive impairment (PSCI) is a common complication following a stroke. Recent findings highlight the role of miR-502-3p in both vascular and neurodegenerative diseases. However, the role in PSCI remains uncovered. OBJECTIVE: This study emphasized the differential expression of miR-502-3p and subsequently evaluated the predictive value of miR-502-3p expression levels for PSCI. MATERIALS AND METHODS: The study subjects included 112 patients with PSCI and 161 individuals with post-stroke cognitive normality. The relative expression of miR-502-3p was calculated by qPCR, while its predictive value for PSCI was assessed via ROC curve. Pearson's correlation coefficient was utilized to analyze the correlation between serum miR-502p-3p levels and PSCI. Multivariate logistic regression was used to identify risk factors of PSCI. RESULTS: Serum miR-502-3p was identified as significantly elevated in the PSCI group. The area under the ROC curve was 0.850, with a sensitivity of 76.79% and a specificity of 77.64%. The miR-502-3p level was positively correlated with both NIHSS and mRS scores. In addition, a negative correlation was observed between the miR-502-3p level and MoCA score. Elevated miR-502-3p and hypertension were identified as independent risk factors for PSCI. CONCLUSION: Significantly elevated serum miR-502-3p was a promising biomarker for the onset of PSCI. Elevated miR-502-3p and hypertension were independent risk factors for PSCI.
Source: Brain and Behavior
DOI: 10.1002/brb3.71208
Authors: Yi Lin, Liang Xu, Yuhao Zhang, Cui Zou
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,630
OpenAlex ID: W7128515569