Work

Effect of Ewe Nutritional Restriction During Gestation on the Number of Sertoli Cells in the Offspring: A Meta‐Analysis

Year: 2026

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: ABSTRACT Maternal nutrition during gestation critically influences foetal reproductive programming. To clarify inconsistent evidence, a meta‐analysis was performed to assess the effect of maternal nutritional restriction on the number of Sertoli cells in ovine offspring. A systematic review in PubMed, Google Scholar, Scopus and Science Direct identified three studies (four comparisons; n = 52). Standardised mean differences (Hedges' g ) were calculated using a random‐effects model. The pooled effect was significant ( g = −0.95, 95% CI: −1.49 to −0.41; p < 0.001), with no heterogeneity ( I 2 = 0%) or publication bias (Egger's test p = 0.616). In conclusion, maternal undernutrition reduces Sertoli cell numbers by approximately one standard deviation.

Source: Reproduction in Domestic Animals

DOI: 10.1111/rda.70185

Authors: Mario A. Espinosa‐Martínez, Héctor Jiménez‐Severiano, Luis J. Montiel‐Olguín

Institution: Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,520