Work

Synthesis of N’-(diphenylmethylene)-3-(amino)propanehydrazide Derivatives and Evaluation for Cholinesterase Inhibitor and Antioxidant Activities

Year: 2025

Type: article

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent form of dementia, affecting millions of individuals worldwide. It is characterized by a gradual decline in cognitive functions, ultimately impairing patients’ ability to perform daily activities. Multiple pathogenic mechanisms have been implicated in AD, including disturbances in the cholinergic system, oxidative stress, metal ion dysregulation, and amyloid-β (Aβ) aggregation.In the present study, four novel N’-(diphenylmethylene)-3-(amino)propanehydrazide derivatives were designed, synthesized, and subsequently evaluated for their cholinesterase inhibitory and antioxidant activities. These compounds may serve as promising starting points for the development of new molecular design strategies targeting AD-related pathways.

Source: EMU Journal of Pharmaceutical Sciences

DOI: 10.54994/emujpharmsci.1834518

Authors: Berfin Güngör, Burcu Kılıç, Deniz Doğruer

Institution: Gazi University

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu